Functionalization of C(sp3)-H bonds adjacent to heterocycles catalyzed by earth abundant transition metals

The inception of C-H bond functionalization of common organic substrates has markedly restructured the retrosynthesis of complex molecules. Among the many classes of C-H bonds, those next to a heteroaromatic ring are exceptionally distinct given the fact that their reactivity are controlled either by coordinating the heteroatom to a transition metal catalyst or by the electronic influences of the ring or both during the C-H cleavage process. While evolvements of these reactions promoted by palladium and/or other heavy transition metal catalysts have emerged in numerous reviews and highlights, a comprehensive review on the earth abundant transition metal-mediated approaches has been long awaited. The recent developments on the functionalization of C(sp(3))-H bonds adjacent to common heterocyclic moieties by means of earth abundant transition metal catalysts are discussed herein. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

The inception of C-H bond functionalization has significantly changed the retrosynthesis of complex molecules, especially those adjacent to heteroaromatic rings. The recent developments in utilizing earth abundant transition metal catalysts for functionalizing C(sp(3))-H bonds next to common heterocyclic moieties have been discussed in this article.