期刊
TETRAHEDRON
卷 98, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.132415
关键词
Earth abundant transition metals; C-H Functionalization; 2-Alkylazaarenes; Azoles; Radical reactions
资金
- DST [DST/INSPIRE/04/2015/002248]
- CSIR (CSMCRI) [MLP 0028]
- UGC
The inception of C-H bond functionalization has significantly changed the retrosynthesis of complex molecules, especially those adjacent to heteroaromatic rings. The recent developments in utilizing earth abundant transition metal catalysts for functionalizing C(sp(3))-H bonds next to common heterocyclic moieties have been discussed in this article.
The inception of C-H bond functionalization of common organic substrates has markedly restructured the retrosynthesis of complex molecules. Among the many classes of C-H bonds, those next to a heteroaromatic ring are exceptionally distinct given the fact that their reactivity are controlled either by coordinating the heteroatom to a transition metal catalyst or by the electronic influences of the ring or both during the C-H cleavage process. While evolvements of these reactions promoted by palladium and/or other heavy transition metal catalysts have emerged in numerous reviews and highlights, a comprehensive review on the earth abundant transition metal-mediated approaches has been long awaited. The recent developments on the functionalization of C(sp(3))-H bonds adjacent to common heterocyclic moieties by means of earth abundant transition metal catalysts are discussed herein. (C) 2021 Elsevier Ltd. All rights reserved.
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