期刊
TETRAHEDRON
卷 95, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.132278
关键词
1-naphthol; Dearomatization; C-alkylation; Naphthalenones
资金
- Estonian Ministry of Education and Research grant [PRG657, PRG1031]
- Centre of Excellence in Molecular Cell Engineering [2014-2020.4.01.15-0013]
- European Regional Development fund grant [2014-2020.4.02.16-0050]
A simple and selective C-alkylation of 1- and 2-naphthols with benzylic and allylic halides was developed, achieving a selective ortho-addition with high yields up to 90% in the presence of organic solvents and additives.
A simple and selective C-alkylation of 1-and 2-naphthols with benzylic and allylic halides was developed. In an organic solvent, like cyclopentyl methyl ether, or toluene in the presence of the ether or alcohol additives, a selective ortho-addition leading to substituted naphthalenones up to 90 % was achieved. (c) 2021 Published by Elsevier Ltd.
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