期刊
TALANTA
卷 228, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2021.122228
关键词
Nickel-doping nanoporous carbon; Electrochemical sensor; Acetaminophen; Determination; Human blood serum and urine samples
资金
- National Natural Science Foundation of China [32072295, 32072296, 31471643, 31571925, 31671930]
- Scientific and Technological Research Foundation of the Department of Education of Hebei Province [QN2019034]
- Natural Science Foundation of Hebei Province [C2020204020, B2020204003, B2020204001, B2016204136, B2016204146, B2017204025]
- Food Processing Discipline Group of Hebei Agricultural University [2020-10]
A sensitive and selective electrochemical sensor for acetaminophen detection in human blood serum and urine samples was developed using nickel-doping nanoporous carbon (Ni/C). The sensor exhibited good linearity and low detection limit, with excellent antiinterference stability and reproducibility, showing great promise for clinical applications.
The sensitive and selective determination of acetaminophen (AP) in the human body is highly desirable to ensure human health. In this work, nickel-doping nanoporous carbon (Ni/C) was fabricated by directly calcining Ni based metal-organic framework (Ni-MOF). The Ni/C based electrochemical sensor was developed for sensitive and selective determination of AP in human blood serum and urine samples. The prepared Ni/C composite possess plentiful catalytic active sites, ordered mesoporous structure and large specific surface area, which endow the constructed Ni/C sensor with a prominent performance for acetaminophen sensing. Under the optimal conditions, the developed method offered good linearity in the range of 0.20-53.75 mu M with a low detection limit (S/N = 3) of 4.04 x 10 (2) mu M. The electrocatalytic performance of the sensor towards AP was further measured by differential pulse voltammetry and cyclic voltammetry. The results demonstrated that the Ni/C sensor can be feasibly employed for the determination of AP in human blood serum and urine samples with excellent antiinterference stability and good reproducibility. The research reveals a great promising of the Ni/C electrochemical sensor for clinical applications and paves a way for the construction of high-performance electrochemical sensors for AP determination.
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