A review on analytical methods with special reference to electroanalytical methods for the determination of some anticancer drugs in pharmaceutical and biological samples

It is widely accepted that cancer, the second leading cause of death, is a morbidity with big impacts on the global health. In the last few years, chemo-therapeutic treatment continually induces alone most lengthy consequents, which is extremely harmful for the physiological and psychological health of the patients. In the present research, we discuss the recent techniques for employed for extraction, and quantitative determination of such compounds in pharmaceutical, and biological specimens. In the frame of this information, this review aims to provide basic principles of chromatography, spectroscopy, and electroanalytical methods for the analysis of anticancer drugs published in the last three years. The review also describes the recent developments regarding enhancing the limit of detection (LOD), the linear dynamic range, and so forth. The results show that the LOD for the chromatographic techniques with the UV detector was obtained equaled over the range 2.0 ng mL(-1)-0.2 mu g mL(-1), whereas the LOD values for analysis by chromatographic technique with the mass spectrometry (MS) detector was found between 10.0 pg mL(-1)-0.002 mu g mL(-1). The biological fluids could be directly injected to capillary electrophoresis (CE) in cases where the medicine concentration is at the contents greater than mg L-1 or g L-1. Additionally, electrochemical detection of the anticancer drugs has been mainly conducted by the voltammetry techniques with diverse modified electrodes, and lower LODs were estimated between 3.0 ng mL 1-0.3 mu g mL(-1). It is safe to say that the analyses of anticancer drugs can be achieved by employing a plethora of techniques such as electroanalytical, spectroscopy, and chromatography techniques.

Automated summary

It is widely accepted that cancer is a major cause of mortality globally and can have significant physiological and psychological impacts on patients, especially those undergoing chemotherapy treatments. This study discusses recent techniques for extracting and quantitatively determining compounds in pharmaceutical and biological samples. The results show that a variety of analytical techniques such as electroanalytical, spectroscopy, and chromatography methods can be employed for the analysis of anticancer drugs.