Synthesis and antimicrobial activity of 4-methylthiazole and 4-thiazolidinone derivatives derived from 5-(aryldiazo)salicylaldehyde thiosemicarbazones

New series of thiazole derivatives were synthesized using 5-(aryldiazo)salicylaldehyde thiosemicarbazones 2a-i. Cyclocondensation of thiosemicarbazones 2a-i with chloroacetone afforded the corresponding 4-methylthiazole derivatives 3a-i. Moreover, cycloalkylation of 2a-i with ethyl bromoacetate afforded the corresponding thiazolidin-4-one derivatives 4a-i. The antimicrobial activity of the new thiazole derivatives was evaluated.

Automated summary

A new series of thiazole derivatives was synthesized using 5-(aryldiazo)salicylaldehyde thiosemicarbazones. The antimicrobial activity of these derivatives was evaluated. Different synthetic methods were used to obtain 4-methylthiazole derivatives and thiazolidin-4-one derivatives.