Total Synthesis of Thiocladospolide A and Its C2-Epimer

The first total synthesis of the recently isolated natural product thiocladospolide A, along with its C2-epimer, is achieved in nine straightforward linear steps and 12% overall yield. The key feature of the synthesis is the construction of the macrocyclic ring via a late-stage ring-closing metathesis reaction followed by alkene reduction.

Automated summary

The first total synthesis of the recently isolated natural product thiocladospolide A, along with its C2-epimer, was achieved in nine straightforward linear steps with a 12% overall yield. The key feature of the synthesis is the construction of the macrocyclic ring via a late-stage ring-closing metathesis reaction followed by alkene reduction.