Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N -Bz Aziridines to Allylic Amides

Herein a bimetallic radical redox-relay strategy is employed to generate alkyl radicals under mild conditions with titanium(III) catalysis and terminated via hydrogen atom transfer with cobalt(II) catalysis to enact base-free isomerizations of N-Bz aziridines to N-Bz allylic amides. This reaction provides an alternative strategy for the synthesis of allylic amides from alkenes via a three-step sequence to accomplish a formal transpositional allylic amination.

Automated summary

A bimetallic radical redox-relay strategy is utilized to generate alkyl radicals with titanium(III) catalysis and terminated via hydrogen atom transfer with cobalt(II) catalysis to achieve base-free isomerizations of N-Bz aziridines to N-Bz allylic amides. This reaction offers an alternative approach for the synthesis of allylic amides from alkenes through a three-step sequence, accomplishing a formal transpositional allylic amination.