The Synthesis of Five-Membered N-Heterocycles by Cycloaddition of Nitroalkenes with (In)Organic Azides and Other 1,3-Dipoles

Cycloaddition reactions have emerged as rapid and powerful methods for constructing heterocycles and carbocycles. [3+2] Cycloadditions of nitroalkenes with various 1,3-dipoles have been an interesting research area for many organic chemists. This review outlines the synthesis of N-substituted and NH-1,2,3-triazoles along with other five-membered N-heterocycles through cycloaddition reactions of nitroalkenes.

Automated summary

Cycloaddition reactions are rapid and powerful tools for constructing heterocycles and carbocycles. The [3+2] cycloadditions of nitroalkenes with various 1,3-dipoles are particularly interesting to organic chemists, leading to the synthesis of N-substituted and NH-1,2,3-triazoles and other five-membered N-heterocycles.