期刊
SYNTHESIS-STUTTGART
卷 53, 期 23, 页码 4341-4352出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1533-3085
关键词
quaternary stereocenters; decarboxylative allylic alkylation; asymmetric catalysis; palladium; synthetic application
资金
- National Natural Science Foundation of China [21901142]
- Natural Science Foundation of Shandong Province [ZR2019QB001, ZR2020QB017]
- Natural Science Foundation of Jiangsu Province [BK20180227]
- Fundamental Research Fund of Shandong University [21310082164009, 21310088963023, 2020QNQT007, 2020QNQT009]
This short review summarizes recent developments in the synthesis of quaternary stereocenters via DAAA methods since 2018, showcasing its potential in organic and medicinal chemistry through representative examples of total synthesis of complex natural products.
Palladium-catalyzed decarboxylative asymmetric allylic alkylation (DAAA) provides an efficient and powerful strategy to construct quaternary stereocenters, which are widely present in biologically active natural products and approved drugs. In this short review, we summarize recent developments (since 2018) in the facile synthesis of quaternary stereocenters via DAAA methods. Several representative examples of the use of DAAA strategies for the total synthesis of complex natural products further demonstrate its synthetic potential in the realm of organic and medicinal chemistry.
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