Asymmetric Synthesis of P-Stereogenic Secondary Phosphine Oxides (SPOs)

P-Stereogenic secondary phosphine oxides [SPOs, RR'P(O)H], valuable ligands for metal complexes in asymmetric catalysis, are also building blocks for other chiral phosphorus derivatives. This short review summarizes methods used for asymmetric synthesis of Pstereogenic SPOs. 1 Introduction 2 Configurational Stability of P-Stereogenic SPOs 3 Classical Resolution, HPLC Separation, and Dynamic Resolution 4 Synthesis via Chiral Auxiliaries 5 Kinetic Resolution 6 Conclusions and Outlook

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This review summarizes methods used for asymmetric synthesis of P-stereogenic secondary phosphine oxides, including classical resolution, HPLC separation, and dynamic resolution among others.