期刊
SYNTHESIS-STUTTGART
卷 54, 期 3, 页码 770-778出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1580-9688
关键词
deep eutectic solvent; dihydropyrano[3,2-c]chromene; zinc chloride; acetamide; 4-hydroxycoumarin
资金
- National Natural Science Foundation of China [11765002, 21966003]
- Science and Technology Project of Jiangxi [20192BBH80012]
An efficient and green method was developed to obtain 4H-pyrano[3,2-c]coumarin derivatives using a deep eutectic solvent (DES) zinc chloride/acetamide. The reaction proceeded in a single step with moderate to high yields and under mild reaction conditions.
4H-Pyrano[3,2-c]coumarin derivatives are an important class of pharmaceutical compounds that are expensive to prepare by previously reported methods. An efficient and green method was developed to obtain these derivatives using the deep eutectic solvent (DES) zinc chloride/acetamide (n:n = 1:4), which acted as both the catalyst and the solvent for the reaction. An aromatic aldehyde, 4-hydroxycoumarin, and cyanoacetate were used as the substrates. The DES, substrate molar ratio, diluent type, temperature, and reaction time were optimized to obtain the 4H-pyrano[3,2-c]coumarin derivatives from a range of aromatic aldehydes in a single step in moderate to high yields and under mild reaction conditions.
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