期刊
SYNTHESIS-STUTTGART
卷 54, 期 4, 页码 953-964出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1529-7739
关键词
annulation; nitrogen-containing heterocycles; aza-ortho-quinone methides; ortho-chloromethyl anilines; 4-atom units
资金
- National Natural Science Foundation of China [21702121]
- 111 Project [D20015]
Aza-ortho-quinone methides are important reactive intermediates with broad applications in synthetic chemistry. The 1,4-elimination of ortho-chloromethyl aniline derivatives has emerged as a novel and powerful method for their generation. This review highlights the recent applications of aza-ortho-quinone methide precursors in annulation reactions to access various biologically important nitrogen-containing heterocycles.
Aza-ortho-quinone methides are important reactive intermediates that have found broad applications in synthetic chemistry. Recently, 1,4-elimination of ortho-chloromethyl aniline derivatives has emerged as a novel, powerful and convenient method for aza-ortho-quinone methide generation. This review will highlight the recent applications of aza-ortho-quinone methide precursors in annulation reactions to access various biologically important nitrogen-containing heterocycles. The general mechanisms are briefly discussed as well. 1 Introduction 2 [4+n] Annulation Reactions Using ortho-Chloromethyl Anilines as Aza-ortho-Quinone Methide Precursors 2.1 [4+2] Annulation Reactions 2.2 [4+1] Annulation Reactions 2.3 [4+3] Annulation Reactions 3 Conclusion and Perspective
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