期刊
SYNTHESIS-STUTTGART
卷 53, 期 23, 页码 4433-4439出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1550-7659
关键词
free-radical lactonization; photoredox catalysis; argentilactone; goniothalamin; unsaturated lactones
资金
- Direccion General de Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico (DGAPA-UNAM) [IN205318]
- Consejo Nacional de Ciencia y Tecnologia [CONACYT] [A1-S-7825, 576554]
The new synthesis approach, based on photoredox catalysis, can be used to synthesize various natural products containing α,β-unsaturated δ-lactones.
alpha,beta-Unsaturated delta-lactones are structural motifs found in diverse pharmacologically active natural products. In fact, the unsaturated lactone is often responsible for the biological activity. Herein, we report a new approach for the syntheses of (R)-argentilactone and (R)-goniothalamin based on a photoredox intermolecular iodolactonization mediated by a photoredox process. This new approach, already employed in our research group, stands as a new methodology to achieve several natural products containing alpha,beta-unsaturated delta-lactones.
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