α-Csp3-H Bond Functionalization of Simple Ethers in Radical Reactions

The direct alpha-Csp (3)-H functionalization of simple ethers is a vital strategy among radical reactions. This review discusses their applications according to the starting materials: (1) reactions with alkenes or alkynes; (2) reactions with other unsaturated compounds; and (3) reactions with nucleophilic partners. Mechanisms like radical addition, C-H activation, elimination, metal-catalyzed coupling, cyclization, oxidation, and rearrangement will be analyzed herein.

Automated summary

The direct alpha-Csp(3)-H functionalization of simple ethers is an important strategy in radical reactions. This review discusses its applications based on different starting materials and analyzes mechanisms such as radical addition, C-H activation, elimination, metal-catalyzed coupling, cyclization, oxidation, and rearrangement.