期刊
SYNTHESIS-STUTTGART
卷 53, 期 20, 页码 3769-3776出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1516-8481
关键词
sulfonylation; radical cross-coupling; cyclobutanone oxime esters; sulfonyl hydrazides catalysis
资金
- Top Youth Talent Fund of Zhengzhou University
- State Key Laboratory of Bio-organic and Natural Products Chemistry, Chinese Academy of Sciences (CAS) [SKLBNPC18440]
This copper-catalyzed reaction allows for the radical cross-coupling of cyclobutanone oxime esters with sulfonyl hydrazides, producing a wide range of diversely substituted cyano-containing sulfones. The method is notable for its low-cost catalytic system, lack of toxic reagents, and use of readily accessible starting materials.
A copper-catalyzed radical cross-coupling of cyclobutanone oxime esters with sulfonyl hydrazides has been developed. The copper-based catalytic system proved crucial for cleavage of the C-C bond of cyclobutanone oximes and for selective C-S bond-formation involving persistent sulfonyl-metal radical intermediates. This protocol is distinguished by the low-cost catalytic system, which does not require ligand, base, or toxic cyanide salt, and by the use of readily accessible starting materials, as well as broad substrate scope, providing an efficient approach to various diversely substituted cyano-containing sulfones.
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