期刊
SYNTHESIS-STUTTGART
卷 53, 期 20, 页码 3673-3682出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1529-7678
关键词
nitrogen heterocycles; isoxazolines; 1,2,3-triazoles; 1,2,5-oxadiazoles; C-H functionalization; ring cleavage; cycloaddition
资金
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-803]
Five-membered heterocyclic N-oxides have significant potential applications in medicinal chemistry and advanced materials science, with recent research focusing on novel methods for their synthesis and functionalization, including transition-metal-catalyzed and metal-free protocols. The transformations of these hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also explored.
Five-membered heterocyclic N-oxides attract special attention due to their significant potential applications in medicinal chemistry and advanced materials science. In this regard, novel methods for their synthesis and functionalization are in constant demand. In this short review, recent state-of-the-art achievements in the chemistry of isoxazoline N-oxides, 1,2,3-triazole 1-oxides and 1,2,5-oxadiazole 2-oxides are summarized. The main routes involving transition-metal-catalyzed and metal-free functionalization protocols along with mechanistic considerations are outlined. The transformations of these hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also presented. 1 Introduction 2 Isoxazoline N-Oxides 3 1,2,3-Triazole 1-Oxides 4 1,2,5-Oxadiazole 2-Oxides 5 Conclusion
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