HMPA-Free Generation of Trialkylsilyllithium Reagents and Its Applications to the Synthesis of Silylboronic Esters

Trialkylsilyllithium species have turned out to be facilely generated by treating hexaalkyldisilanes with methyllithium in the presence of tris(N,N-tetramethylene)phosphoric triamide (TPPA) as an activator, which can be trapped by boron electrophiles to afford silylboronic esters including long-awaited Me-3 Si-B(pin).

Automated summary

Trialkylsilyllithium species can be easily generated under specific conditions and trapped by boron electrophiles. This method allows for the preparation of silylboronic esters.