Synthesis of α-exo-Methylene-γ-butyrolactones: Recent Developments and Applications in Natural Product Synthesis

The alpha-exo-methylene-gamma-butyiolactone moiety is present in a vast array of structurally diverse natural products and is often central to their biological activity. In this short review, we summarize new approaches to alpha-exo-methylene-gamma-butyrolactones developed over the past decade as well as their applications in total synthesis.

Automated summary

The review summarizes new approaches to alpha-exo-methylene-gamma-butyrolactones developed over the past decade as well as their applications in total synthesis, highlighting the significance of the alpha-exo-methylene-gamma-butyiolactone moiety in structurally diverse natural products.