期刊
SYNLETT
卷 32, 期 14, 页码 1428-1432出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1533-1080
关键词
alkynylation; tryptanthrin; indoloquinazolinone; copper catalysis
资金
- National Natural Science Foundation of China [21571144]
- Natural Science Foundation of Zhejiang Province [LY18B020011, LQ19B020004]
- Foundation of Zhejiang Educational Committee [Y201839490]
The study describes a copper-catalyzed direct alkynylation reaction of tryptanthrins with terminal alkynes, resulting in the synthesis of 6-alkynyl-6-hydroxyindoloquinazolinone compounds in moderate to good yields under mild reaction conditions with varied functional group compatibility. The obtained adducts can be smoothly converted into versatile building blocks via hydrogenation, hydration, and further Sonogashira coupling transformations.
We report a copper-catalyzed direct alkynylation reaction of tryptanthrins with terminal alkynes under mild reaction conditions. The developed method provides an array of synthetic building blocks of 6-alkynyl-6-hydroxyindoloquinazolinone compounds in moderate to good yields with varied functional group compatibility. Furthermore, the obtained adducts can be smoothly converted into versatile building blocks via hydrogenation, hydration, and further Sonogashira coupling transformations.
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