期刊
SYNAPSE
卷 75, 期 9, 页码 -出版社
WILEY
DOI: 10.1002/syn.22215
关键词
calyx of Held; development; mice; rat; residual glutamate current
资金
- National Research Foundation of Korea [2020R1A2C2006438]
- Seoul National University Hospital
- National Research Foundation of Korea [2020R1A2C2006438] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study found that certain parameters of calyx synapses in rats and mice gradually approached mature levels at P14, and further matured at P16 or P18, indicating that the maturation process of calyx synapses continues at these stages.
Although calyx of Held synapses undergo dramatic changes around the hearing onset, previous in vivo studies suggest that the calyx synapses undergo further post-hearing maturation process. While developmental changes over the hearing onset have been extensively studied, this post-hearing maturation process remained relatively little investigated. Because of post-hearing maturation, previous results from studies around hearing onset and studies of post-hearing calyx synapses are somewhat inconsistent. Here, we characterized the post-hearing maturation of calyx synapses with regard to in vitro electrophysiological properties in rats and mice. We found that parameters for residual glutamate in the cleft during a train, EPSC kinetics, and vesicle pool size became close to a full mature level by P14, but they further matured until P16 in the rats. Consistently, the phasic and slow EPSCs evoked by action potential trains at P16 calyx synapses were not different from those at P18 or P25 under physiological extracellular [Ca2+](o) (1.2 mM). In contrast, the parameters for residual current and EPSC kinetics displayed drastic changes until P16 in mice, and slow EPSCs during the train further decreased between P16 and P18, suggesting that maturation of calyx synapses progresses at least up to P16 in rats and P18 in mice.
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