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Comment on: Toll-like receptor 4 and MyD88 are required for gastric bypass-induced metabolic effects

SURGERY FOR OBESITY AND RELATED DISEASES (2021)

A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

Patrice D. Cani et al.

Summary: The study identified a novel protein (P9) secreted by Akkermansia muciniphila that stimulates GLP-1 secretion, providing new insights for treating metabolic diseases.

CELL METABOLISM (2021)

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Article Surgery

Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects

Marwa Abu El Haija et al.

Summary: Toll-like receptor 4 (TLR4) and myeloid differentiation factor 8 (MyD88) play important roles in the metabolic response induced by Roux-en-Y gastric bypass surgery (RYGB), mainly mediated by gut microbiota. TLR4 knockout mice show attenuated glucose regulatory response to RYGB, while MyD88 knockout mice do not respond to the metabolic effects induced by RYGB. Fecal microbiota transplant from RYGB-operated mice fails to induce a metabolic phenotype similar to that of the donors in TLR4 and MyD88 KO mice, but is successful in wild-type recipients.

SURGERY FOR OBESITY AND RELATED DISEASES (2021)

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Article Endocrinology & Metabolism

Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity

Fernando F. Anhe et al.

NATURE METABOLISM (2020)

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Article Cell Biology

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

Robert Caesar et al.

CELL METABOLISM (2015)

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Article Gastroenterology & Hepatology

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

Robert Caesar et al.

GUT (2012)

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Comment on: Toll-like receptor 4 and MyD88 are required for gastric bypass-induced metabolic effects

相关参考文献

A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects

Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

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