In vitro degradation assessment of calcium fluoride-doped hydroxyapatite coating prepared by pulsed laser deposition

The surface properties of bone tissue engineered scaffolds are essential for cell attachment, proliferation, and differentiation. Calcium fluoride-doped hydroxyapatite (F-HA) coating prepared by pulsed laser deposition can rapidly form a nanopore structure through ion exchange in the simulated body fluid. Results showed that F-HA coating can accelerate the apatite-like deposition and improve the corrosion resistance of the coating. Results also revealed that F-HA coating can promote cell proliferation (p < 0.05). Briefly, F- HA coating can mimic the porous structure of natural bones and be for surface modification of bone tissue engineered scaffolds, so as to promote new bone growth.

Automated summary

The F-HA coating, forming a nanopore structure through ion exchange in simulated body fluid, can accelerate apatite-like deposition, enhance corrosion resistance, and promote cell proliferation.