期刊
SURFACE & COATINGS TECHNOLOGY
卷 422, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.surfcoat.2021.127508
关键词
Smart biomaterials; Hybrid coatings; Bone regeneration; Cardiovascular stents; Drug eluting coatings; Cell therapy
资金
- MCIU/AEI/FEDER, UE [RTI2018096391-B-C33]
- ADITIMAT-CM [S2018/NMT-4411]
- Ministerio de Ciencia e Innovacion
- Instituto de Salud Carlos III Sara Borrell Fellowship [CD19/00136]
- Ministerio de Ciencia e Innovacion [RTI2018-096328B-I00]
- [RYC-2017 21843]
- [PEJD-2019-POST/IND-16119]
This review discusses the state-of-the-art strategies for design and fabrication of smart biomaterials for tissue engineering, focusing on metallic biomaterials with hybrid coatings. It outlines key technologies for designing hybrid smart and multifunctional coatings on metallic cores for bone regeneration implants and cardiovascular stents, and highlights recent progress in incorporating drug-eluting functionality into these materials.
The review encompasses state-of-the-art strategies for design and fabrication of smart biomaterials for tissue engineering. The focus of the work is mainly put on metallic biomaterials with hybrid coatings consisting of bioceramic and polymeric layers with hierarchical organization and drug-eluting capacity. Key technologies and steps to design hybrid smart and multifunctional coatings on metallic cores for bone regeneration implants and cardiovascular stents are outlined, including additive manufacturing of titanium and magnesium alloys for permanent and temporary implant applications. Three levels of hierarchical surface functionalization are described: i) in situ modification of the core material, incorporating bioactive inorganic species and phases by means of ceramic coatings via anodic electrochemical treatments; ii) post-treatment application of polymer layers, monolithic or with specific porous breath figure topography; and iii) application of a cellular therapy component (single cell or cell sheet). Recent progress in incorporation of drug-eluting functionality into such materials via direct or nanocarrier-assisted loading is also highlighted.
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