期刊
SURFACE & COATINGS TECHNOLOGY
卷 422, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.surfcoat.2021.127453
关键词
Ti-6Al-4V implant; Nanosecond laser; Zinc oxide; Micro grooves; Biocompability
资金
- National Natural Science Foundation of China [51975336]
- Key Research and Development Program of Shandong Province [2020JMRH0202, 2019JZZY010112]
- Natural Science Foundation of Shandong Province [2017G006010]
- Advanced Medical Research Institute of Shandong University
Micro grooves coated with zinc oxide were successfully manufactured on Ti-6Al-4V surface through two-step nanosecond laser treatment to investigate the synergistic effects of micro/nano structures and Zn2+ on cell adhesion, proliferation, and differentiation. Results showed significantly improved roughness and hydrophilicity on the laser-processing surface compared to the acid etching surface, with the appearance of ZnO diffraction peak. The coated micro grooves showed great potential in promoting the adhesion, proliferation, and differentiation of MC3T3 cells.
Surface morphology of implants plays an important role in enhancing cell response at the interface. Zinc ions (Zn2+) have a promising potential for osseointegration by stimulating osteoblast cell multiplication and differentiation. In this study, regular micro grooves coated with zinc oxide (ZnO) were successfully manufactured on Ti-6Al-4V surface by two-step nanosecond laser treatment to investigate the synergetic effects of micro/nano structures and Zn2+ on the cell adhesion, proliferation and differentiation. Surface characteristics including surface morphology, roughness, wettability and phase composition were characterized. Results showed that the roughness and hydrophilicity of laser-processing surface were significantly improved compared with those of the acid etching surface. Moreover, XRD results indicated that the ZnO diffraction peak appeared on the surface. The biocompatibility of different samples was investigated by cell experiment in vitro. The spreading morphology of cells along grooves, cell multiplication rate, and activity of alkaline phosphatase and osteocalcin indicated that the micro grooves coated with ZnO on Ti-6Al-4V surface had great potential to promote the adhesion, multiplication and differentiation of MC3T3 cells. This study provides a new and effective method for surface modification of Ti-6Al-4V implants.
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