4.7 Article

Disconnectomics of the Rich Club Impacts Motor Recovery After Stroke

期刊

STROKE
卷 52, 期 6, 页码 2115-2124

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.120.031541

关键词

brain; cluster analysis; communication; connectome; diffusion-weighted imaging; upper extremity

资金

  1. Personalized Health and Related Technologies (PHRT) [2017-205]
  2. Defitech Foundation (Strike-the-Stroke, Morges, Switzerland)
  3. Wyss Foundation (Geneva, Switzerland) [AVANCER-WCP030]
  4. Bertarelli Foundation (Deep-MCI-T, Gstaad, Switzerland)
  5. National Research Foundation of Korea (NRF) [2020R1A2C3010304]
  6. National Research Foundation of Korea [2020R1A2C3010304] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

The study explores the role of rich-club in poststroke recovery through network-theoretical quantification of lesions in patients with ischemic stroke. Results indicate that smaller lesions focusing on the rich-club can be just as devastating as larger lesions that do not, emphasizing the importance of the rich-club in functional communication within brain networks and recovery from stroke.
BACKGROUND AND PURPOSE: Structural brain networks possess a few hubs, which are not only highly connected to the rest of the brain but are also highly connected to each other. These hubs, which form a rich-club, play a central role in global brain organization. To investigate whether the concept of rich-club sheds new light on poststroke recovery, we applied a novel network-theoretical quantification of lesions to patients with stroke and compared the outcomes with what lesion size alone would indicate. METHODS: Whole-brain structural networks of 73 patients with ischemic stroke were reconstructed using diffusion-weighted imaging data. Disconnectomes, a new type of network analyses, were constructed using only those fibers that pass through the lesion. Fugl-Meyer upper extremity scores and their changes were used to determine whether the patients show natural recovery or not. RESULTS: Cluster analysis revealed 3 patient clusters: small-lesion-good-recovery, midsized-lesion-poor-recovery (MLPR), and large-lesion-poor-recovery (LLPR). The small-lesion-good-recovery consisted of subjects whose lesions were small, and whose prospects for recovery were relatively good. To explain the nondifference in recovery between the MLPR and LLPR clusters despite the difference (LLPR>MLPR) in lesion volume, we defined the metric to be the sum of the entries in the disconnectome and, more importantly, the to be the sum of all entries in the disconnectome corresponding to edges with at least one node in the rich-club. Unlike lesion volume and corticospinal tract damage (MLPRLLPR) or showed no difference for L-1. CONCLUSIONS: Smaller lesions that focus on the rich-club can be just as devastating as much larger lesions that do not focus on the rich-club, pointing to the role of the rich-club as a backbone for functional communication within brain networks and for recovery from stroke.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据