期刊
STEM CELL RESEARCH
卷 54, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scr.2021.102416
关键词
-
资金
- Ministry of Science and Technology (MOST) [MOST 109-2740-B-001002]
The study generated induced pluripotent stem cell lines with the homozygous form of ALDH2, which can be used as a useful platform to study alcohol metabolism and chronic diseases associated with alcohol consumption.
ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). These cell lines were characterized in terms of pluripotency and differentiation potential. They serve as useful platforms to study alcohol metabolism and other chronic diseases associated with alcohol consumption.
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