期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 266, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.120407
关键词
Fluorescent probe; Cell membrane; Azide; Bioimaging; H2S
类别
资金
- National Natural Science Foundation of China [21777053, 21607053]
- Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program [2019KJD005]
- Shandong Provincial Natural Science Foundation [ZR2017MB014]
- Innovation Team Project of Colleges and Universities in Jinan [2019GXRC027]
Hydrogen sulfide is an environmental pollutant and an important gas signal molecule closely related to many diseases. A new H2S fluorescence probe called PCM has been developed, which can detect endogenous and exogenous H2S, distinguish them, and potentially become a new chemical tool for research on H2S-related diseases.
Hydrogen sulfide (H2S), a recognized environmental pollutant, comes from a wide range of sources. For example, H2S will be produced in the process of plant protein corruption, the decomposition of domestic sewage and garbage, food processing (wine brewing), etc. and once the concentration is too high, it will cause significant damage of environment and human body. Besides H2S is an important gas signal molecule in vivo, which can be transferred through lipid membrane. Its existence level is closely related to many diseases. If we can visually trace the transmembrane transmission of hydrogen sulfide, it will be very helpful for the study of oxidative stress processes, cell protection, signal transduction and related diseases closely related to H2S. Although some probes can detect H2S in environment, cytoplasm and organelles, there are few reports on the release and internalization of H2S. In this work, we report a H2S fluorescence probe that can retain on the cell membrane, named PCM. The probe PCM can not only detect endogenous and exogenous H2S, but also distinguish them, this provides a general strategy for the construction of probes to detect other biomarkers. In addition, PCM has been successfully applied to the detection of endogenous and exogenous H2S in zebrafish, which has the potential to become a new chemical tool and provide help for the research of H2S-related diseases. (C) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据