期刊
SMALL
卷 17, 期 32, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202101495
关键词
bacterial infection; biofilm; l-arginine-rich peptide dendrimers; NO gas therapy; photodynamic antibacterial therapy; wound healing
类别
资金
- National Natural Science Foundation of China [51503131, 51703245]
- Natural Science Foundation of Jiangsu Province [BK20181377, BK20170733]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
This study presents a novel synergistic antibacterial strategy based on PDT and NO gas therapy using Ce6@Arg-ADP as a carrier, which shows enhanced biofilm penetration and antibacterial effects. The combination of O-1(2) and NO offers notable synergistic effects, promoting wound healing effectively.
The development of alternative strategies for the efficient treatment of subcutaneous abscesses that do not require the massive use of antibiotics and surgical intervention is urgently needed. Herein, a novel synergistic antibacterial strategy based on photodynamic (PDT) and NO gas therapy is reported, in which, a PDT-driven NO controllable generation system (Ce6@Arg-ADP) is developed with l-Arg-rich amphiphilic dendritic peptide (Arg-ADP) as a carrier. This carrier not only displays superior bacterial association and biofilm penetration performance, but also acts as a versatile NO donor. Following efficient penetration into the interior of the biofilms, Ce6@Arg-ADP can rapidly produce massive NO via utilizing the H2O2 generated during PDT to oxidize Arg-ADP to NO and l-citrulline, without affecting singlet oxygen (O-1(2)) production. The combination of O-1(2) and the reactive by-products of NO offers notable synergistic antibacterial and biofilm eradication effects. Importantly, following efficient elimination of all bacteria from the abscess site, Arg-ADP can further generate trace quantities of NO to facilitate the angiogenesis and epithelialization of the wound tissues, thereby notably promotes wound healing. Together, this study clearly suggests that Arg-ADP is a versatile NO donor, and the combination of PDT and NO represents a promising strategy for the efficient treatment of subcutaneous abscesses.
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