期刊
SMALL
卷 17, 期 37, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202102035
关键词
eco-friendly and scalable synthesis; epidermal stem cells; free radical scavenging; fullerenols; skin radioprotection
类别
资金
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
- National Basic Research Program of China [2020YFA0710702, 2016YFA2021600]
- National Natural Science Foundation of China [51822207, 51772292, 52003031]
- Chinese Academy of Sciences Youth Innovation Promotion Association [2013007]
- CAS Key Research Program of Frontier Sciences [QYZDJ-SSW-SLH022]
This study provides a simple, scalable, and eco-friendly method for synthesizing fullerenols, explores their skin radioprotective effects, and demonstrates their significant protective role on skin.
Radiation dermatitis is a common but torturous side effect during radiotherapy, which greatly decreases the life quality of patients and potentially results in detrimental cessation of tumor treatment. Fullerenol, known as free radical sponge, is a great choice for skin radioprotection because of its broad-spectrum free radical scavenging performance, good chemical stability, and biosafety. In this work, a facile scalable and eco-friendly synthetic method of fullerenols by catalyst assistant mechanical chemistry strategy is provided. As no organic solvent or high concentration of acid and alkali is introduced to this synthetic system, large-scale (>20 g) production of fullerenols with high yield (>95%) is obtained and no complicated purification is required. Then, the skin radioprotective performance of fullerenols is systematically explored for the first time. In vitro results indicate that fullerenols significantly block the reactive oxygen species-induced damage and enhance the viability of irradiated human keratinocyte cells. In vivo experiments suggest that medical sodium hyaluronate hydrogels loaded with fullerenols are suitable for skin administration and powerfully mitigate radiodermatitis via effectively protecting epidermal stem cells. The work not only provides an efficient gram-scale and eco-friendly synthetic method of fullerenols, but also promotes the development of fullerenols as potential skin radioprotectors.
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