期刊
SMALL
卷 17, 期 30, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202101770
关键词
aggregation-induced emission; human coronaviruses; membrane targeting; photodynamic therapy; photosensitizers
类别
资金
- Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet
- National Natural Science Foundation of China [31720103906, 22005050, 21708030]
- Applied Basic Research of Sichuan Province [2021YJ0397]
- National Key Research and Development Program of China [2019YFA0904300]
- Innovation Group Project of Natural Science Foundation of Hubei Province
This study reports the efficient inactivation of human coronavirus with photodynamic therapy using photosensitizers with aggregation-induced emission characteristics. The photosensitizer can effectively target and inactivate the virus under light irradiation, providing a new avenue for combating COVID-19 with photodynamic therapy.
COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2, has resulted in global social and economic disruption, putting the world economy to the largest global recession since the Great Depression. To control the spread of COVID-19, cutting off the transmission route is a critical step. In this work, the efficient inactivation of human coronavirus with photodynamic therapy (PDT) by employing photosensitizers with aggregation-induced emission characteristics (DTTPB) is reported. DTTPB is designed to bear a hydrophilic head and two hydrophobic tails, mimicking the structure of phospholipids on biological membranes. DTTPB demonstrates a broad absorption band covering the whole visible light range and high molar absorptivity, as well as excellent reactive oxygen species sensitizing ability, making it an excellent candidate for PDT. Besides, DTTPB can target membrane structure, and bind to the envelope of human coronaviruses. Upon light irradiation, DTTPB demonstrates highly effective antiviral behavior: human coronavirus treated with DTTPB and white-light irradiation can be efficiently inactivated with complete loss of infectivity, as revealed by the significant decrease of virus RNA and proteins in host cells. Thus, DTTPB sensitized PDT can efficiently prevent the infection and the spread of human coronavirus, which provides a new avenue for photodynamic combating of COVID-19.
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