期刊
SMALL
卷 17, 期 52, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202101460
关键词
carrier-free; combination therapy; nanotechnology; prodrug; self-assembly; stimuli-response
类别
资金
- National Natural Science Foundation of China [81872816]
- Liaoning Revitalization Talents Program [XLYC180801]
- Shenyang Youth Science and Technology Innovation Talents Program [RC190454]
- China Postdoctoral Innovative Talents Support Program [BX20190219]
- China Postdoctoral Science Foundation [2019M661134]
SMP-NAs, formed by the self-assembly of prodrugs, have been widely investigated for their ultrahigh drug-loading and minimal adverse reactions, offering potential for improved antitumor efficiency compared to traditional nanomedicines. They are being used in chemotherapy, phototherapy, immunotherapy, and tumor diagnosis, and their co-delivery capabilities can address the challenges of tumor heterogeneity and multidrug resistance. Smart stimuli-responsive SMP-NAs and combination therapies based on SMP-NAs are also highlighted, emphasizing the structure-function relationships.
The antitumor efficiency and clinical translation of traditional nanomedicines is mainly restricted by low drug loading, complex preparation technology, and potential toxicity caused by the overused carrier materials. In recent decades, small-molecule prodrug nanoassemblies (SMP-NAs), which are formed by the self-assembly of prodrugs themselves, have been widely investigated with distinct advantages of ultrahigh drug-loading and negligible excipients-trigged adverse reaction. Benefited from the simple preparation process, SMP-NAs are widely used for chemotherapy, phototherapy, immunotherapy, and tumor diagnosis. In addition, combination therapy based on the accurate co-delivery behavior of SMP-NAs can effectively address the challenges of tumor heterogeneity and multidrug resistance. Recent trends in SMP-NAs are outlined, and the corresponding self-assembly mechanisms are discussed in detail. Besides, the smart stimuli-responsive SMP-NAs and the combination therapy based on SMP-NAs are summarized, with special emphasis on the structure-function relationships. Finally, the outlooks and potential challenges of SMP-NAs in cancer therapy are highlighted.
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