期刊
SLEEP
卷 44, 期 11, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsab147
关键词
REM sleep without atonia; atonia index; chin EMG tone; SSRI antidepressants; narcolepsy type 1; children
资金
- Italian Ministry of Health [2764043]
The study found that selective serotonin reuptake inhibitor (SSRI) antidepressants can modify chin electromyogram (EMG) tone in children during sleep, and different SSRI medications may have differential effects on chin tone during sleep.
Study Objectives: To assess if selective serotonin reuptake inhibitor (SSRI) antidepressants are able to modify the chin electromyogram (EMG) tone during sleep also in children. Methods: Twenty-three children and adolescents (12 girls, mean age 14.1 years, SD 2.94) under therapy with antidepressant for their mood disorder were consecutively recruited and had a PSG recording. Twenty-one were taking were taking SSRI and treatment duration was 2-12 months. An age- and sex matched group of 33 control children (17 girls, mean age 14.2 years, SD 2.83) and 24 children with narcolepsy type 1 (12 girls, mean age 13.7 years, SD 2.80) were also included.The Atonia Index was then computed for each NREM sleep stage and for REM sleep, also all EMG activations were counted. Results: Atonia Index in all sleep stages was found to be significantly reduced in children with narcolepsy followed by the group taking SSRI antidepressants and the number of EMG activations was also increased in both groups. Fluoxetine, in particular, was found to be significantly associated with reduced Atonia index during NREM sleep stages N1, N2, and N3, and with an increased number of EMG activations/hour during sleep stage N3. Conclusions: Similarly to adults, SSRI antidepressants are able to modify the chin EMG tone in children during REM sleep, as well as during NREM sleep stages. Different pharmacological properties of the different SSRI might explain the differential effect on chin tone during sleep found in this study.
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