4.6 Article

Cutaneous α-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder

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Summary: The study developed and tested an automated bright-field immunohistochemical assay for cutaneous pathological alpha-synuclein deposition in patients with idiopathic rapid eye movement sleep behavior disorder, PD, and atypical parkinsonism. Results showed that skin biopsy could be used to diagnose both clinical and prodromal PD.

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