期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 349, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.130773
关键词
Aptamer; Aptamer-drug conjugates (ApDCs); Fluorescent imaging; Nucleolin; Drug release
资金
- National Natural Science Foundation of China [21432008, 91753201, 21721005]
The study introduces a novel method combining aptamer binding and catalytic reactions to regulate drug release under pathological conditions, reducing drug toxicity and showing great potential for application in cancer treatment.
Chemotherapy remains an effective treatment for cancer today. However, it remains a huge challenge due to side effects. In the current study, we first introduce aptamer-linked chemical decaging reactions combine with endogenous copper ions or Cu-chelates to regulate the release of prodrugs in pathological conditions. For the proof-of-concept study, we use aptamers with rhodamine to target imaging of nucleolin overexpressing cancer cells, where nucleolin aptamers not only act as targets, but surprisingly also cooperate with copper ions to accelerate the release of fluorescent moieties. We construct activatable prodrugs models nucleic acid aptamers and conventional chemotherapy to target nucleolin overexpressing cancer cells, in which reduced drug toxicity can be activated by adding copper ions. We envision that the integration of binding aptamer and catalytic reactions based on small molecules has a promising application in the field of cancer treatment.
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