期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 340, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.129904
关键词
Nitrogen-doped carbon quantum dots; Dual-excitation to dual-emission; 'On-off-on' fluorescent probe; Cell imaging
资金
- National Natural Science Foundation of China [21375117]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Postgraduate research/practice innovation program of Jiangsu province
A dual-on-off-on fluorescent probe based on nitrogen-doped carbon quantum dots (BG-NCDs) was developed for detecting Fe(III), AA, Cu(II), and GSH. The method displayed high sensitivity, wide detection range, good practicality, low cytotoxicity, and successful multicolor imaging of DU145 cells.
A dual-on-off-on fluorescent probe based on nitrogen-doped carbon quantum dots (BG-NCDs) with the dualexcitation property was developed, which had a blue emission peak at 398 nm and a green emission peak at 518nm when excited at 298nm and 404nm, respectively. BG-NCDs were characterized by TEM, XPS, and FT-IR. The results showed that (1) the Fe (III) and ascorbic acid (AA) could turn off/turn on the blue fluorescence of BG-NCDs, the blue fluorescence of BG-NCDs was used as an on-off-on fluorescent probe to detecting the Fe (III) and AA in the linear ranges of 0.04-20.00 mg/L and 0.57-10.00 mg/L, the LODs were as low as 0.012 mg/L and 0.19 mg/L; (2) the presence of Cu (II) and glutathione (GSH) could turn off/turn on the green fluorescence of BG-NCDs, the on-off-on process of green fluorescence of BG-NCDs could be established as a fluorescence probe to detecting Cu (II) and GSH in the linear ranges of 1.08-16.00 mg/L and 2.46-32.00 mg/L, with LODs of 0.36 mg/L and 0.86 mg/L. The method was applied to determination analytes in real samples with satisfactory results. BG-NCDs displayed low cytotoxicity and was multicolored imaging DU145 cells successfully.
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