期刊
SEMINARS IN LIVER DISEASE
卷 41, 期 3, 页码 358-367出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0041-1730923
关键词
MRGRPX4; cholestasis; pruritus
资金
- NIH
This passage discusses the debilitating symptom of pruritus in liver diseases with cholestasis and the recent identification of MRGPRX4 as a receptor for bile acids and bilirubin in cholestatic itch. It summarizes current theories and knowledge of cholestatic itch, emphasizing MRGPRX4 as a key mediator and discussing future perspectives in this area of research.
Pruritus (itch) is a debilitating symptom in liver diseases with cholestasis, which severely affects patients' quality of life. Limited treatment options are available for cholestatic itch, largely due to the incomplete understanding of the underlying molecular mechanisms. Several factors have been proposed as pruritogens for cholestatic itch, such as bile acids, bilirubin, lysophosphatidic acid, and endogenous opioids. Recently, two research groups independently identified Mas-related G protein-coupled receptor X4 (MRGPRX4) as a receptor for bile acids and bilirubin and demonstrated its likely role in cholestatic itch. This discovery not only opens new avenues for understanding the molecular mechanisms in cholestatic itch but provides a promising target for developing novel anti-itch treatments. In this review, we summarize the current theories and knowledge of cholestatic itch, emphasizing MRGPRX4 as a bile acid and bilirubin receptor mediating cholestatic itch in humans. We also discuss some future perspectives in cholestatic itch research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据