期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 121, 期 -, 页码 82-98出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2021.08.002
关键词
Karyopherins; Nucleocytoplasmic transport; Testis; Spermatogenesis; Development; ScRNAseq
资金
- Australian Research Council [DP200103463]
- JSPS KAKENHI [20K06455]
- Victorian State Government Operational Infrastructure Scheme
- Deutsche Forschungsgemeinschaft (DFG)
- Monash University [GRK 1871/1]
- Australian Research Council [DP200103463] Funding Source: Australian Research Council
- Grants-in-Aid for Scientific Research [20K06455] Funding Source: KAKEN
Regulated nucleocytoplasmic transport is crucial for changes in gene expression during cellular development and homeostasis. This paper provides an overview of the functions of importin proteins, with a focus on their roles in testis development and spermatogenesis.
Regulated nucleocytoplasmic transport is central to the changes in gene expression that underpin cellular development and homeostasis, including in the testis, and proteins in the importin family are the predominant facilitators of cargo transport through the nuclear envelope. Reports documenting cell-specific profiles of importin transcripts and proteins during spermatogenesis led us to hypothesize that importins facilitate developmental switches in the testis. More recently, importins have been shown to serve additional functions, both inside and outside the nucleus; these include acting as subcellular scaffolding, mediating cellular stress responses, and controlling transcription. This paper seeks to provide an overview and update on the functions of importin proteins, with a focus on testis development and spermatogenesis. We present an extended survey of importins by combining published single cell RNAseq data with immunohistochemistry on developing and adult mouse testes. This approach reinforces and broadens knowledge of importins in biological processes, including in spermatogenesis and during testis development, revealing additional avenues for impactful investigations.
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