4.6 Review

Nonclassical androgen and estrogen signaling is essential for normal spermatogenesis

期刊

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 121, 期 -, 页码 71-81

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2021.05.032

关键词

Testis; Sertoli cell; Steroid hormone receptors; Efferent ductules; Rete testis; Sperm

资金

  1. NIH [R01 PR015540]
  2. Pennsylvania Department of Health

向作者/读者索取更多资源

This review summarizes the physiological functions of classical and nonclassical androgen and estrogen signaling pathways in the testis and reproductive tract. The study highlights the essential role of nonclassical signaling in the overall response to hormones, and the abnormalities in spermatogenesis and the male reproductive tract associated with the absence of either nonclassical or classical receptor pathways.
Signaling by androgens through androgen receptor (AR) is essential to complete spermatogenesis in the testis. Similarly, loss of the main estrogen receptor, estrogen receptor 1 (ESR1; also known as ER alpha), results in male infertility, due in part to indirect deleterious effects on the seminiferous epithelium and spermatogenesis. Effects of steroid hormones are induced primarily through genomic changes induced by hormone-mediated activation of their intracellular receptors and subsequent effects on nuclear gene transcription. However, androgens and estrogens also signal through rapid nonclassical pathways involving actions initiated at the cell membrane. Here we review the data that nonclassical androgen and estrogen signaling pathways support processes essential for male fertility in the testis and reproductive tract. The recent development of transgenic mice lacking nonclassical AR or ESR1 signaling but retaining genomic nuclear signaling has provided a powerful tool to elucidate the function of nonclassical signaling in the overall response to androgens and estrogens. Results from these mice have emphasized that nonclassical signaling is essential for full responses to these hormones, and absence of either nonclassical or classical AR or ESR1 pathways produces abnormalities in spermatogenesis and the male reproductive tract. Although additional work is required to fully understand how classical and nonclassical receptor signaling synergize to produce full steroid hormone responses, here we summarize the known physiological functions of the classical and nonclassical androgen and estrogen signaling pathways in the testis and reproductive tract.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据