相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Circulating microRNA-590-5p functions as a liquid biopsy marker in non-small cell lung cancer
Akanksha Khandelwal et al.
CANCER SCIENCE (2020)
Sustained release of silibinin-loaded chitosan nanoparticle induced apoptosis in glioma cells
Maryam Alipour et al.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)
Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion
Lingling Si et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)
Inhibition of urinary bladder cancer cell proliferation by silibinin
Tatiane M. B. Barros et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2020)
Tumor-targeted delivery of silibinin and IPI-549 synergistically inhibit breast cancer by remodeling the microenvironment
Min Jiang et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)
Co-delivery of silybin and paclitaxel by dextran-based nanoparticles for effective anti-tumor treatment through chemotherapy sensitization and microenvironment modulation
Meirong Huo et al.
JOURNAL OF CONTROLLED RELEASE (2020)
Clinical outcome of breast cancer in carriers of BRCA1 and BRCA2 mutations according to molecular subtypes
Solene De Talhouet et al.
SCIENTIFIC REPORTS (2020)
Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis
Ying Liu et al.
JOURNAL OF NANOBIOTECHNOLOGY (2020)
Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer
Yanting You et al.
FRONTIERS IN PHARMACOLOGY (2020)
Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
Dominique Delmas et al.
MOLECULES (2020)
Estrogen receptors participate in silibinin-caused nuclear translocation of apoptosis-inducing factor in human breast cancer MCF-7 cells
Weiwei Liu et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)
Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
Uttam Sharma et al.
TRANSLATIONAL ONCOLOGY (2020)
The miR-15a/16 gene cluster in human cancer: A systematic review
Ting Liu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Cabazitaxel and silibinin co-encapsulated cationic liposomes for CD44 targeted delivery: A new insight into nanomedicine based combinational chemotherapy for prostate cancer
Shaheen Mahira et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Design, optimization and in vitro-in vivo evaluation of smart nanocaged carrier delivery of multifunctional PEG-chitosan stabilized silybin nanocrystals
Yangyang Liu et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)
Silibinin inhibits ultraviolet B radiation-induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch( plus /-) mouse model of basal cell carcinoma
Cindy Rigby et al.
MOLECULAR CARCINOGENESIS (2019)
Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment
Lingling Si et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)
Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells
Silvia Zappavigna et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Silibinin encapsulation in polymersome: A promising anticancer nanoparticle for inducing apoptosis and decreasing the expression level of miR-125b/miR-182 in human breast cancer cells
Samaneh Hossainzadeh et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review
Vahid Soleimani et al.
PHYTOTHERAPY RESEARCH (2019)
The Dark That Matters: Long Non-coding RNAs as Master Regulators of Cellular Metabolism in Non-communicable Diseases
Alessia Mongelli et al.
FRONTIERS IN PHYSIOLOGY (2019)
Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation
Anjali Takke et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)
Silibinin inhibited autophagy and mitochondrial apoptosis in pancreatic carcinoma by activating JNK/SAPK signaling
Xiaokai Zhang et al.
PATHOLOGY RESEARCH AND PRACTICE (2019)
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer
Suraksha Tamang et al.
FRONTIERS IN ONCOLOGY (2019)
miR-200c suppresses stemness and increases cellular sensitivity to trastuzumab in HER2+breast cancer
Hailin Tang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)
Metabolism, Transport and Drug-Drug Interactions of Silymarin
Ying Xie et al.
MOLECULES (2019)
Silibinin declines blue light-induced apoptosis and inflammation through MEK/ERK/CREB of retinal ganglion cells
Ying Shen et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)
Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy
Akshay Malhotra et al.
BIOCHIMIE (2019)
Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulation
Zhengzheng Shi et al.
LIFE SCIENCES (2019)
A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties
Valeria Romanucci et al.
MOLECULES (2019)
Topical silymarin administration for prevention of acute radiodermatitis in breast cancer patients: A randomized, double-blind, placebo-controlled clinical trial
Hedyieh Karbasforooshan et al.
PHYTOTHERAPY RESEARCH (2019)
Solid Lipid Nanoparticles and Chitosan-coated Solid Lipid Nanoparticles as Promising Tool for Silybin Delivery: Formulation, Characterization, and In vitro Evaluation
Vieri Piazzini et al.
CURRENT DRUG DELIVERY (2019)
Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells
Jiyeon Ham et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2018)
Matrix metallopeptidase 9 targeted by hsa-miR-494 promotes silybin-inhibited osteosarcoma
Tianhao Sun et al.
MOLECULAR CARCINOGENESIS (2018)
Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line
Seyede Elmira Yazdi Rouholamini et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)
Enhancement of anticancer activity by silibinin and paclitaxel combination on the ovarian cancer
Fatima Pashaei-Asl et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)
Role of silibinin in the management of diabetes mellitus and its complications
Chun Chu et al.
ARCHIVES OF PHARMACAL RESEARCH (2018)
Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT
Jie Mao et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2018)
Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression
Daniela Catanzaro et al.
FITOTERAPIA (2018)
Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies
Zhong-Wen Yuan et al.
PHARMACOLOGICAL RESEARCH (2018)
Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats
W. W. Tong et al.
SCIENTIFIC REPORTS (2018)
Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP
Zhuan-Li Bai et al.
BIOMED RESEARCH INTERNATIONAL (2018)
Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway
Xiaoying Hou et al.
FRONTIERS IN PHARMACOLOGY (2018)
In vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L.
Sirajudheen Anwar et al.
INDIAN JOURNAL OF PHARMACOLOGY (2018)
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
Jacob O'Brien et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator
Zohreh Jahanafrooz et al.
LIFE SCIENCES (2018)
Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway
Rongjuan Zheng et al.
MEDIATORS OF INFLAMMATION (2018)
Silibinin, A Natural Blend In Polytherapy Formulation For Targeting Cd44v6 Expressing Colon Cancer Stem Cells
Shanaya Patel et al.
SCIENTIFIC REPORTS (2018)
Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line
Sana Nafees et al.
ARCHIVES OF MEDICAL RESEARCH (2018)
Multifunctional Nanosystem for Targeted and Controlled Delivery of Multiple Chemotherapeutic Agents for the Treatment of Drug Resistant Breast Cancer
Song Lou et al.
ACS OMEGA (2018)
Synergistic Anti-proliferative Effects of Metformin and Silibinin Combination on T47D Breast Cancer Cells via hTERT and Cyclin D1 Inhibition
Mina Chatran et al.
DRUG RESEARCH (2018)
Crosstalk of ROS/RNS and autophagy in silibinin-induced apoptosis of MCF-7 human breast cancer cells in vitro
Nan Zheng et al.
ACTA PHARMACOLOGICA SINICA (2017)
Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status
Daiane Teixeira de Oliveira et al.
JOURNAL OF BIOSCIENCES (2017)
Silibinin Inhibits Hypoxia- Induced HIF-1α- Mediated Signaling, Angiogenesis, and Lipogenesis in Prostate Cancer Cells: In Vitro Evidence and In Vivo Functional Imaging and Metabolomics
Gagan Deep et al.
MOLECULAR CARCINOGENESIS (2017)
A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma
Ioannis Anestopoulos et al.
MOLECULES (2017)
Silibinin sensitizes chemo-resistant breast cancer cells to chemotherapy
Ommoleila Molavi et al.
PHARMACEUTICAL BIOLOGY (2017)
A new drug nanocrystal self-stabilized Pickering emulsion for oral delivery of silybin
Tao Yi et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Silibinin inhibits the fibrotic responses induced by cigarette smoke via suppression of TGF-β1/Smad 2/3 signaling
Je-Won Ko et al.
FOOD AND CHEMICAL TOXICOLOGY (2017)
miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer
Michaela Strotbek et al.
INTERNATIONAL JOURNAL OF CANCER (2017)
Mechanistic insight into carnosol-mediated pharmacological effects: Recent trends and advancements
Dharambir Kashyap et al.
LIFE SCIENCES (2017)
Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism
Michal Bijak
MOLECULES (2017)
Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer
C. Miethe et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2017)
Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells
Hyo Joo Byun et al.
ONCOLOGY REPORTS (2017)
Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling
Arpit Dheeraj et al.
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2017)
Topical Silymarin Administration for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Sepideh Elyasi et al.
PHYTOTHERAPY RESEARCH (2017)
Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascade
Eun-Sun Choi et al.
CELLULAR ONCOLOGY (2017)
Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability
Muhammad Umar Khayam Sahibzada et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2017)
Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models
Michal Bijak et al.
NUTRIENTS (2017)
The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer
Akshay Malhotra et al.
ONCOTARGET (2017)
Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer
Valentina Belli et al.
Oncotarget (2017)
Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways
Mitsuho Imai-Sumida et al.
ONCOTARGET (2017)
Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells
Soumaye Amirsaadat et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)
HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies
Haneen Amawi et al.
FRONTIERS IN PHARMACOLOGY (2017)
Increased Loading, Efficacy and Sustained Release of Silibinin, a Poorly Soluble Drug Using Hydrophobically-Modified Chitosan Nanoparticles for Enhanced Delivery of Anticancer Drug Delivery Systems
Cha Yee Kuen et al.
NANOMATERIALS (2017)
The emerging role of long non-coding RNA in gallbladder cancer pathogenesis
Akanksha Khandelwal et al.
BIOCHIMIE (2017)
Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer
Xin-yue Dong et al.
ACTA PHARMACOLOGICA SINICA (2017)
Nanoencapsulation Improves Scavenging Capacity and Decreases Cytotoxicity of Silibinin and Pomegranate Oil Association
Marila C. L. Marchiori et al.
AAPS PHARMSCITECH (2017)
Alginate/Gelatin scaffolds incorporated with Silibinin-loaded Chitosan nanoparticles for bone formation in vitro
R. S. Leena et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2017)
History, Discovery, and Classification of lncRNAs
Julien Jarroux et al.
LONG NON CODING RNA BIOLOGY (2017)
Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo
Mrinmay Chakrabarti et al.
APOPTOSIS (2016)
A Presurgical Study of Oral Silybin-Phosphatidylcholine in Patients with Early Breast Cancer
Matteo Lazzeroni et al.
CANCER PREVENTION RESEARCH (2016)
D Role of AMPK signaling inmediating the anticancer effects of silibinin in esophageal squamous cell carcinoma
Jin Li et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2016)
ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells
Nan Zheng et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)
Development of pH-sensitive self-nanoemulsifying drug delivery systems for acid-labile lipophilic drugs
Tianjing Zhao et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2016)
In vitro drug release characteristic and cytotoxic activity of silibinin-loaded single walled carbon nanotubes functionalized with biocompatible polymers
Julia Meihua Tan et al.
CHEMISTRY CENTRAL JOURNAL (2016)
Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer - A comprehensive review
Navaneethakrishnan Polachi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Silibinin derivatives as anti-prostate cancer agents: Synthesis and cell-based evaluations
Bao Vue et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells
Masoud Maleki Zadeh et al.
JOURNAL OF BREAST CANCER (2016)
Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives
Gaurav Kumar et al.
LIFE SCIENCES (2016)
PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications
Cecilia C. Torres et al.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)
Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Sepideh Elyasi et al.
PHYTOTHERAPY RESEARCH (2016)
Molecular targets of gambogic acid in cancer: recent trends and advancements
Dharambir Kashyap et al.
TUMOR BIOLOGY (2016)
Inhibitory effects of silibinin on proliferation and lung metastasis of human high metastasis cell line of salivary gland adenoid cystic carcinoma via autophagy induction
Canhua Jiang et al.
ONCOTARGETS AND THERAPY (2016)
Silibinin: a potential old drug for cancer therapy
Xing-Xing Zhu et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2016)
Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy
Komal Raina et al.
JOURNAL OF BIOMEDICAL RESEARCH (2016)
Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells
Sang-Hun Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells
Wan Feng et al.
BIOMEDICINE & PHARMACOTHERAPY (2015)
Synergistic anti-tumor actions of luteolin and silibinin prevented cell migration and invasion and induced apoptosis in glioblastoma SNB19 cells and glioblastoma stem cells
Mrinmay Chakrabarti et al.
BRAIN RESEARCH (2015)
MicroRNA-7: a promising new target in cancer therapy
Juanjuan Zhao et al.
CANCER CELL INTERNATIONAL (2015)
Synthesis of New Silybin Derivatives and Evaluation of Their Antioxidant Properties
Armando Zarrelli et al.
HELVETICA CHIMICA ACTA (2015)
Autophagy Induction by Silibinin Positively Contributes to Its Anti-Metastatic Capacity via AMPK/mTOR Pathway in Renal Cell Carcinoma
Feng Li et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
Enhancement of the cytotoxic effects of Cytarabine in synergism with Hesperidine and Silibinin in Acute Myeloid Leukemia: An in-vitro approach
Urja N. Desai et al.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2015)
ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells
Nan Zheng et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2015)
Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects
Hardeep Singh Tuli et al.
LIFE SCIENCES (2015)
Long non-coding RNA: A new paradigm for lung cancer
Akanksha Khandelwal et al.
MOLECULAR CARCINOGENESIS (2015)
Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma
Zhenkun Ma et al.
ONCOLOGY REPORTS (2015)
Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
Kai Jiang et al.
ONCOLOGY REPORTS (2015)
Isothiocyanates: a class of bioactive metabolites with chemopreventive potential
Gaurav Kumar et al.
TUMOR BIOLOGY (2015)
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas
Yu-Chao Chang et al.
ONCOTARGET (2015)
Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
Surendra K. Shukla et al.
ONCOTARGET (2015)
Laser light triggered smart release of silibinin from a PEGylated-PLGA gold nanocomposite
E. Fazio et al.
JOURNAL OF MATERIALS CHEMISTRY B (2015)
Silibinin Prevents Prostate Cancer Cell-Mediated Differentiation of Naive Fibroblasts into Cancer-Associated Fibroblast Phenotype by Targeting TGF β2
Harold J. Ting et al.
MOLECULAR CARCINOGENESIS (2015)
Silibinin Inhibits Proliferation, Induces Apoptosis and Causes Cell Cycle Arrest in Human Gastric Cancer MGC803 Cells Via STAT3 Pathway Inhibition
Yi-Xin Wang et al.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2014)
MiR-200, a new star miRNA in human cancer
Xiangling Feng et al.
CANCER LETTERS (2014)
A Phase I Dose-Finding Study of Silybin Phosphatidylcholine (Milk Thistle) in Patients With Advanced Hepatocellular Carcinoma
Abby B. Siegel et al.
INTEGRATIVE CANCER THERAPIES (2014)
Fabrication, characterization and bioevaluation of silibinin loaded chitosan nanoparticles
Deep Pooja et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2014)
The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells
L. Gandara et al.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2014)
Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-κB, and AP-1 activation in RAW264.7 cells
Chandagirikoppal V. Kavitha et al.
MOLECULAR CARCINOGENESIS (2014)
Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling
Gagan Deep et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2014)
Chemistry of silybin
D. Biedermann et al.
NATURAL PRODUCT REPORTS (2014)
Enhanced cytotoxicity and apoptosis-induced anticancer effect of silibinin-loaded nanoparticles in oral carcinoma (KB) cells
M. Gohulkumar et al.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2014)
Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer
Parvin Forghani et al.
CANCER MEDICINE (2014)
Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer
Harold Ting et al.
AAPS JOURNAL (2013)
Energy deprivation by silibinin in colorectal cancer cells A double-edged sword targeting both apoptotic and autophagic machineries
Komal Raina et al.
AUTOPHAGY (2013)
In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells
Dhanya Nambiar et al.
CANCER LETTERS (2013)
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
Antero Salminen et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
HiFSA Fingerprinting Applied to Isomers with Near-Identical NMR Spectra: The Silybin/Isosilybin Case
Jose G. Napolitano et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Mechanistic Study of the Biomimetic Synthesis of Flavonolignan Diastereoisomers in Milk Thistle
Hanan S. Althagafy et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Effect of silibinin in human colorectal cancer cells: Targeting the activation of NF-κB signaling
Komal Raina et al.
MOLECULAR CARCINOGENESIS (2013)
Chemopreventive and Anti-Cancer Efficacy of Silibinin Against Growth and Progression of Lung Cancer
Samiha Mateen et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2013)
Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells
Yuanxin Zhang et al.
PHYTOTHERAPY RESEARCH (2013)
Silybin-Mediated Inhibition of Notch Signaling Exerts Antitumor Activity in Human Hepatocellular Carcinoma Cells
Song Zhang et al.
PLOS ONE (2013)
Epigenetic effects of the natural flavonolignan silibinin on colon adenocarcinoma cells and their derived metastatic cells
Henriette Kauntz et al.
ONCOLOGY LETTERS (2013)
Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo
Silvia Cufi et al.
SCIENTIFIC REPORTS (2013)
Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Upregulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells
Samiha Mateen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Silibinin – A Promising New Treatment for Cancer
Catherine Wing Ying Cheung et al.
Anti-Cancer Agents in Medicinal Chemistry (2012)
The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells
Henriette Kauntz et al.
APOPTOSIS (2012)
Integrative transcriptome analysis suggest processing of a subset of long non-coding RNAs to small RNAs
Saakshi Jalali et al.
BIOLOGY DIRECT (2012)
Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells
Y. Zhang et al.
CELL BIOCHEMISTRY AND FUNCTION (2012)
Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells
Samiha Mateen et al.
EPIGENETICS (2012)
P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells
Simiao Fan et al.
FREE RADICAL RESEARCH (2012)
P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK
Simiao Fan et al.
FREE RADICAL RESEARCH (2012)
Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells
Yang Yu et al.
FREE RADICAL RESEARCH (2012)
Silibinin Inhibits the Invasion of IL-6-Stimulated Colon Cancer Cells via Selective JNK/AP-1/MMP-2 Modulation in Vitro
Chiu-Mei Lin et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)
In Vivo Evaluation of Silybin Nanosuspensions Targeting Liver
Yancai Wang et al.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2012)
Silibinin Activated p53 and Induced Autophagic Death in Human Fibrosarcoma HT1080 Cells via Reactive Oxygen Species-p38 and c-Jun N-Terminal Kinase Pathways
Wen-Jun Duan et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
Silibinin-Induced Apoptosis in MCF7 and T47D Human Breast Carcinoma Cells Involves Caspase-8 Activation and Mitochondrial Pathway
Prabha Tiwari et al.
CANCER INVESTIGATION (2011)
In vitro antitumor activity of silybin nanosuspension in PC-3 cells
Dandan Zheng et al.
CANCER LETTERS (2011)
Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells
Yuan-yuan Jiang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells
Binbin Liu et al.
FREE RADICAL RESEARCH (2011)
Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells
Yakun Ge et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)
Silibinin activated ROS-p38-NF-kappa positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells
Wen-Jun Duan et al.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2011)
Silibinin Enhances Ultraviolet B-Induced Apoptosis in MCF-7 Human Breast Cancer Cells
Eun-Mi Noh et al.
JOURNAL OF BREAST CANCER (2011)
Chemopreventive and Chemotherapeutic Effects of Intravesical Silibinin against Bladder Cancer by Acting on Mitochondria
Jin Zeng et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Silibinin Inhibits the Invasion and Migration of Renal Carcinoma 786-O Cells In Vitro, Inhibits the Growth of Xenografts In Vivo and Enhances Chemosensitivity to 5-Fluorouracil and Paclitaxel
Horng-Rong Chang et al.
MOLECULAR CARCINOGENESIS (2011)
Neuroprotective effect of silibinin in diabetic mice
Giuseppina Marrazzo et al.
NEUROSCIENCE LETTERS (2011)
Topical Use of a Silymarin-Based Preparation to Prevent Radiodermatitis Results of a Prospective Study in Breast Cancer Patients
Martina Becker-Schiebe et al.
STRAHLENTHERAPIE UND ONKOLOGIE (2011)
THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY - A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL
Ales Vidlar et al.
BIOMEDICAL PAPERS-OLOMOUC (2010)
A Randomized, Controlled, Double-Blind, Pilot Study of Milk Thistle for the Treatment of Hepatotoxicity in Childhood Acute Lymphoblastic Leukemia (ALL)
Elena J. Ladas et al.
CANCER (2010)
Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer
Gagan Deep et al.
CANCER AND METASTASIS REVIEWS (2010)
Chemoprevention of Intestinal Tumorigenesis in APCmin/+ Mice by Silibinin
Subapriya Rajamanickam et al.
CANCER RESEARCH (2010)
Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies
Lejiao Jia et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2010)
Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells
Hong-Jun Wang et al.
FREE RADICAL RESEARCH (2010)
Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C
Roy L. Hawke et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2010)
Silibinin Induced Autophagic and Apoptotic Cell Death in HT1080 Cells Through a Reactive Oxygen Species Pathway
Wenjun Duan et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2010)
In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery
Yancai Wang et al.
NANOTECHNOLOGY (2010)
Silibinin Exerts Sustained Growth Suppressive Effect against Human Colon Carcinoma SW480 Xenograft by Targeting Multiple Signaling Molecules
Balaiya Velmurugan et al.
PHARMACEUTICAL RESEARCH (2010)
Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity-role of individual hydroxyl groups
Radek Gazak et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells
Marco Trappoliere et al.
JOURNAL OF HEPATOLOGY (2009)
Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft
Manjinder Kaur et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model
Komal Raina et al.
CANCER RESEARCH (2008)
Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis
Rana P. Singh et al.
CANCER RESEARCH (2008)
Silibinin Inhibits Established Prostate Tumor Growth, Progression, Invasion, and Metastasis and Suppresses Tumor Angiogenesis and Epithelial-Mesenchymal Transition in Transgenic Adenocarcinoma of the Mouse Prostate Model Mice
Rana P. Singh et al.
CLINICAL CANCER RESEARCH (2008)
The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants
Yiftach Vaknin et al.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2008)
Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft
Rana P. Singh et al.
CARCINOGENESIS (2007)
Silybin is metabolized by cytochrome P4502C8 in vitro
Petra Jancova et al.
DRUG METABOLISM AND DISPOSITION (2007)
Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer
Fawn S. Hogan et al.
JOURNAL OF SURGICAL RESEARCH (2007)
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis
Kyungwon Min et al.
ARCHIVES OF PHARMACAL RESEARCH (2007)
Silibinin sensitizes human glioma cells to TRAIL-Mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin
Yong-Gyu Son et al.
CANCER RESEARCH (2007)
Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.)
Carmen Tamayo et al.
INTEGRATIVE CANCER THERAPIES (2007)
Toward the definition of the mechanism of action of silymarin: Activities related to cellular protection from toxic damage induced by chemotherapy
Maria Cristina Comelli et al.
INTEGRATIVE CANCER THERAPIES (2007)
Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice
Mallikarjuna Gu et al.
CANCER RESEARCH (2007)
A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
Thomas W. Flaig et al.
INVESTIGATIONAL NEW DRUGS (2007)
Silybin and silymarin - New and emerging applications in medicine
Radek Gazak et al.
CURRENT MEDICINAL CHEMISTRY (2007)
Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms
Komal Raina et al.
ACTA PHARMACOLOGICA SINICA (2007)
The efficacy of Silybum marianum (L.) Gaertn. (Silymarin) in the treatment of type II diabetes:: A randomized, double-blind, placebo-controlled, clinical trial
H. Fallah Huseini et al.
PHYTOTHERAPY RESEARCH (2006)
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2
Alpna Tyagi et al.
CARCINOGENESIS (2006)
Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice
Syed M. Meeran et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
C Hoh et al.
CLINICAL CANCER RESEARCH (2006)
Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA:: Effectiveness of a dietary supplement
FH Schröder et al.
EUROPEAN UROLOGY (2005)
The pleiotropic role of autophagy: from protein metabolism to bactericide
N Mizushima
CELL DEATH AND DIFFERENTIATION (2005)
DNA methylation and human disease
KD Robertson
NATURE REVIEWS GENETICS (2005)
Two-year results of a randomised double-blinded trial evaluating silymarin for chronic hepatitis C
GT Strickland et al.
DIGESTIVE AND LIVER DISEASE (2005)
Stereoselective metabolism of silybin diastereoisomers in the glucuronidation process
YH Han et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2004)
Prostate cancer prevention by silibinin
RP Singh et al.
CURRENT CANCER DRUG TARGETS (2004)
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages
A Tyagi et al.
CARCINOGENESIS (2004)
A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer
RP Singh et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2004)
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
C Agarwal et al.
ONCOGENE (2003)
Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents?
G Gasparini et al.
LANCET ONCOLOGY (2003)
Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death
S Dhanalakshmi et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, isolated from Silybum marianum (milk thistle)
DYW Lee et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Commercially available herbal preparation and its modified dispense in patients with functional dyspepsia. Results of a double-blind, placebo-controlled, randomized multicenter trial
A Madisch et al.
ZEITSCHRIFT FUR GASTROENTEROLOGIE (2001)
The use of silymarin in the treatment of liver diseases
R Saller et al.
DRUGS (2001)
The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
A Cano et al.
NATURE CELL BIOLOGY (2000)
分享论文
