期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 13, 期 605, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.abj6946
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资金
- National Institutes of Health/National Cancer Institute [R01 CA258784]
- Druckenmiller Center for Lung Cancer Research
- Memorial Sloan Kettering Cancer Center
- Parker Institute for Cancer Immunotherapy
- Congressionally Directed Medical Research Programs/Lung Cancer Research Programs Investigator-Initiated Translational Research Award
- Lung Cancer Foundation of America/Bristol Myers Squibb/International Lung Cancer Foundation Young Investigator Award in Translational Immuno-oncology
- Lung Cancer Research Foundation
Targeting replication stress response proteins in small cell lung cancer can activate the innate immune cGAS-STING pathway, leading to enhanced antitumor response of immunotherapy.
Targeting replication stress response proteins in small cell lung cancer activates the innate immune cGAS-STING pathway leading to augmentation of immunotherapy's antitumor response.
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