期刊
SCIENCE CHINA-LIFE SCIENCES
卷 65, 期 3, 页码 500-514出版社
SCIENCE PRESS
DOI: 10.1007/s11427-021-1975-9
关键词
Hedgehog signaling; protein kinase A (PKA); primary cilium; centrosome; compartmentalized cell signaling
类别
资金
- National Institutes of Health [CA235749]
This article reviews recent studies on the role of PKA in Hh signaling, highlighting the compartmentalization of PKA in the centrosome and primary cilium. It also outlines the genetic and optical tools that have been developed to study PKA activities during Hh signal transduction.
The Hedgehog (Hh) signaling is one of the essential signaling pathways during embryogenesis and in adults. Hh signal transduction relies on primary cilium, a specialized cell surface organelle viewed as the hub of cell signaling. Protein kinase A (PKA) has been recognized as a potent negative regulator of the Hh pathway, raising the question of how such a ubiquitous kinase specifically regulates one signaling pathway. We reviewed recent genetic, molecular and biochemical studies that have advanced our mechanistic understanding of PKA's role in Hh signaling in vertebrates, focusing on the compartmentalized PKA at the centrosome and in the primary cilium. We outlined the recently developed genetic and optical tools that can be harvested to study PKA activities during the course of Hh signal transduction.
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