4.7 Article

A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds

期刊

SCIENCE CHINA-CHEMISTRY
卷 64, 期 10, 页码 1736-1742

出版社

SCIENCE PRESS
DOI: 10.1007/s11426-021-1072-6

关键词

iodination; tiacumicin; metal-free; facile chemistry

资金

  1. Key Science and Technology Project of Hainan Province (Key Science and Technology Project) [ZDKJ202018]
  2. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [2019ZD0406]
  3. Chinese Academy of Sciences [QYZDJ-SSW-DQC004]
  4. National Natural Science Foundation of China [81872778, 31630004, 41911530078]
  5. Ministry of Science and Technology of China [2018YFC1406705]

向作者/读者索取更多资源

A facile and nonenzymatic iodination method for didechlorotiacumicin B was discovered during the study on halide compatibility of TiaM, which also showed compatibility with other 9 aromatic substrates for iodination.
Tiacumicin B (also known as fidaxomicin or difimicin) is a marketed 18-membered macrolide antibiotic for the treatment of Clostridium difficile infections. Tiacumicin B is structurally characterized with two chlorine atoms substituted on the aromatic ring, which is installed by the halogenase TiaM. During the study on halide compatibility of TiaM, a facile and nonenzymatic iodination method of didechlorotiacumicin B was discovered, requiring NaI, acid and air for iodination at room temperature. This method was also amenable to other 9 aromatic substrates with electron-rich sites for iodination.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据