期刊
SCIENCE
卷 373, 期 6556, 页码 813-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aba3683
关键词
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资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education [2020R1A6A3A03037326]
- Vaadia-BARD Postdoctoral Fellowship [FI-5052014]
- Public Health Service Grant [AI044170, AI096528, AI112445, AI112949, AI146432, AI153069, TR001861]
- Dorothy Beryl and Theodore Roe Austin Pathology Research Fund [T32AI112541, T32DK007673-07, T32ES007028-46]
- U.S. Department of Agriculture (USDA) [2032-51530-025-00D]
- USDA/NIFA [2015-67015-22930]
- Crohn's and Colitis Foundation of America Senior Investigator Award [650976]
- V Foundation for Cancer Research [V2020-013]
- Vanderbilt Digestive Disease Pilot and Feasibility grant [P30 058404]
- ACS Institutional Research Grant [IRG-19-139-59]
- VICC GI SPORE grant [P50CA236733]
- United States-Israel Binational Science Foundation [2019136]
- Vanderbilt Institute for Clinical and Translational Research Grant [VR53102, VR54267]
- National Research Foundation of Korea [2020R1A6A3A03037326] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.
A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to a high-fat diet escalates Escherichia coli choline catabolism by altering intestinal epithelial physiology. A high-fat diet impaired the bioenergetics of mitochondria in the colonic epithelium to increase the luminal bioavailability of oxygen and nitrate, thereby intensifying respiration-dependent choline catabolism of E. coli. In turn, E. coli choline catabolism increased levels of circulating trimethlamine N-oxide, which is a potentially harmful metabolite generated by gut microbiota.
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