Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

Emerging studies indicate that the immune system can regulate systemic metabolism. Here, we show that thymic stromal lymphopoietin (TSLP) stimulates T cells to induce selective white adipose loss, which protects against obesity, improves glucose metabolism, and mitigates nonalcoholic steatohepatitis. Unexpectedly, adipose loss was not caused by alterations in food intake, absorption, or energy expenditure. Rather, it was induced by the excessive loss of lipids through the skin as sebum. TSLP and T cells regulated sebum release and sebum-associated antimicrobial peptide expression in the steady state. In human skin, TSLP expression correlated directly with sebum-associated gene expression. Thus, we establish a paradigm in which adipose loss can be achieved by means of sebum hypersecretion and uncover a role for adaptive immunity in skin barrier function through sebum secretion.

Automated summary

The study reveals a new mechanism in which the immune system regulates systemic metabolism, with T cells inducing white adipose loss through excessive sebum secretion. This adipose loss protects against obesity, improves glucose metabolism, and is not caused by alterations in food intake, absorption, or energy expenditure. The findings highlight the role of adaptive immunity in skin barrier function through sebum secretion.