期刊
SCIENCE
卷 373, 期 6555, 页码 655-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abg5289
关键词
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资金
- NSF [IOS-1744001, IOS-1546727, IOS-1127112, IOS-1546719, IOS-1822330, IOS-1856627, DBI-1905869, 1650042, 1744592, DGE-1545463, IOS-1546657]
- USDA [2018-67013-27571]
- USDA-ARS [8062-21000-041-00D, 58-5030-8-064, 5030-21000-068-00D]
- NIH-OD [S10 OD028632]
- USDA Hatch project [CA-D-PLS-2066-H]
The study reports de novo genome assemblies, transcriptomes, annotations, and methylomes for 26 maize inbreds, with over 103,000 pangenes identified. It shows that the ancient tetraploid character of maize continues to degrade by fractionation, and reveals variation in DNA methylation levels across genotypes.
We report de novo genome assemblies, transcriptomes, annotations, and methylomes for the 26 inbreds that serve as the founders for the maize nested association mapping population. The number of pangenes in these diverse genomes exceeds 103,000, with approximately a third found across all genotypes. The results demonstrate that the ancient tetraploid character of maize continues to degrade by fractionation to the present day. Excellent contiguity over repeat arrays and complete annotation of centromeres revealed additional variation in major cytological landmarks. We show that combining structural variation with single-nucleotide polymorphisms can improve the power of quantitative mapping studies. We also document variation at the level of DNA methylation and demonstrate that unmethylated regions are enriched for cis-regulatory elements that contribute to phenotypic variation.
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