期刊
SCIENCE
卷 373, 期 6557, 页码 889-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abj0113
关键词
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M010996/1, BB/M011224/1]
- Wellcome Trust [206298/Z/17/Z-ARTIC, 203783/Z/16/Z, 204311/Z/16/Z]
- European Research Council [725422-ReservoirDOCS]
- Branco Weiss Fellowship
- European Union's Horizon 2020 project MOOD [874850]
- Oxford Martin School
- Rockefeller Foundation
- Fondation Botnar Research Award [6063]
- UK Cystic Fibrosis Trust (Innovation Hub) [001]
- Fonds National de la Recherche Scientifique (FNRS
- Belgium)
- Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen) [G0E1420N, G098321N]
- Interne Fondsen KU Leuven/Internal Funds KU Leuven [C14/18/094]
- Medical Research Council (MRC), UK Research and Innovation (UKRI)
- National Institute of Health Research (NIHR)
- Genome Research Limited
- Fast Grants [2236]
- Clarendon Scholarship
- University of Oxford
- NERC DTP [NE/S007474/1]
- Royal Society [204311/Z/16/Z]
- Medical Research Council-Sao Paulo Research Foundation CADDE partnership award [MR/S0195/1, FAPESP 18/14389-0]
- Wellcome Trust [203783/Z/16/Z] Funding Source: Wellcome Trust
Understanding the spatial invasion dynamics of the B.1.1.7 lineage, researchers found a multistage process with early growth rates linked to human mobility and asymmetric lineage export from dominant source locations. Additionally, they explored how the spread of B.1.1.7 was influenced by nonpharmaceutical interventions and spatial variation in previous attack rates. The study emphasizes the importance of considering behavioral and epidemiological contexts in accurately interpreting the growth rates of emerging variants of concern.
Understanding the causes and consequences of the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern is crucial to pandemic control yet difficult to achieve because they arise in the context of variable human behavior and immunity. We investigated the spatial invasion dynamics of lineage B.1.1.7 by jointly analyzing UK human mobility, virus genomes, and community-based polymerase chain reaction data. We identified a multistage spatial invasion process in which early B.1.1.7 growth rates were associated with mobility and asymmetric lineage export from a dominant source location, enhancing the effects of B.1.1.7's increased intrinsic transmissibility. We further explored how B.1.1.7 spread was shaped by nonpharmaceutical interventions and spatial variation in previous attack rates. Our findings show that careful accounting of the behavioral and epidemiological context within which variants of concern emerge is necessary to interpret correctly their observed relative growth rates.
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