☆ 4.8 Article

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

SCIENCE (2021)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Immunology

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Annika Nelde et al.

Summary: SARS-CoV-2-specific T cell epitopes were identified in convalescent and unexposed individuals, showing cross-reactivity with common cold coronaviruses. The diversity of SARS-CoV-2 T cell responses may be associated with mild symptoms of COVID-19.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection

Daniel Poston et al.

Summary: Although cross-reactive immune responses may affect SARS-CoV-2 susceptibility and disease outcomes, neutralizing activity against SARS-CoV-2 was not detected in prepandemic sera with prior seasonal coronavirus infection.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Recent endemic coronavirus infection is associated with less-severe COVID-19

Manish Sagar et al.

Summary: The study suggests that individuals with prior endemic coronavirus infections were tested more frequently for respiratory infections, but had similar rates of acquiring SARS-CoV-2. Additionally, patients with previous endemic coronavirus infections experienced less severe cases of COVID-19.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Cell Biology

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

Anthony T. Tan et al.

Summary: This study found that early induction of interferon-gamma (IFN-gamma) secreting SARS-CoV-2-specific T cells was present in patients with mild disease and accelerated viral clearance, while rapid induction and quantity of humoral responses were associated with an increase in disease severity. These findings highlight the importance of early functional SARS-CoV-2-specific T cells in both vaccine design and immune monitoring.

CELL REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

Elizabeth M. Anderson et al.

Summary: Our research indicates that most individuals had antibodies against other seasonal human coronaviruses before the COVID-19 pandemic. Around 20% of these individuals also had antibodies that cross-reacted with SARS-CoV-2, but these antibodies did not offer protection against SARS-CoV-2 infections or hospitalizations.

CELL (2021)

添加到收藏夹

Letter Medicine, General & Internal

Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients

Sharon Amit et al.

LANCET (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes

Chadi M. Saad-Roy et al.

Summary: Given vaccine dose shortages and logistical challenges, various deployment strategies are being proposed to increase population immunity levels to SARS-CoV-2. While focusing on one dose may decrease infections in the short term, the long-term outcomes depend on the relative immune robustness of this approach. Under conditions of partial population immunity, a one-dose policy may increase the potential for antigenic evolution.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Longitudinal antibody repertoire in mild versus severeCOVID-19 patients reveals immune markers associated with disease severity and resolution

Supriya Ravichandran et al.

Summary: Limited information exists on immune markers associated with disease severity or recovery in COVID-19 patients. This study revealed different dynamics of antibody repertoire evolution in severe versus mild patients, with mild patients showing more favorable immune response for early recovery. High-titer IgA against RBD was observed in severe patients, especially those who succumbed to the infection, while mild patients demonstrated increased antibody affinity maturation associated with faster recovery.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Biology

Immunoreactive peptide maps of SARS-CoV-2

Nischay Mishra et al.

Summary: Mishra, Huang et al. identified 29 linear SARS-CoV-2 epitopes that are immunoreactive with plasma from individuals who had asymptomatic, mild, or severe SARS-CoV-2 infections. This study suggests the possibility of using these peptides to discriminate the exposure to SARS-CoV-2 and other human coronaviruses.

COMMUNICATIONS BIOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality

William R. Morgenlander et al.

Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

Galit Alter et al.

Summary: The Ad26.COV2.S vaccine has shown clinical efficacy against symptomatic COVID-19, including the B.1.351 variant, but there is uncertainty regarding its immunogenicity against SARS-CoV-2 variants. The study found that neutralizing antibody responses were reduced against the B.1.351 and P.1 variants, while non-neutralizing antibody responses and T cell responses were largely preserved against SARS-CoV-2 variants.

NATURE (2021)

添加到收藏夹

Article Immunology

Deconvoluting the T Cell Response to SARS-CoV-2: Specificity Versus Chance and Cognate Cross-Reactivity

Alexander A. Lehmann et al.

Summary: SARS-CoV-2 infection may not induce a durable antibody response in all infected individuals, leading researchers to focus on specific T cell memory against the virus.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

Alison Tarke et al.

Summary: By studying T cell responses in 99 convalescent COVID-19 cases, we identified various HLA-restricted epitopes derived from SARS-CoV-2 and observed distinct patterns of immunodominance. The epitopes were combined into megapools to facilitate the identification and quantification of virus-specific CD4(+) and CD8(+) T cells.

CELL REPORTS MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

Alba Grifoni et al.

CELL (2020)

添加到收藏夹

Article Biology

Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones

Anastasia A. Minervina et al.

ELIFE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

Chek Meng Poh et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Virological assessment of hospitalized patients with COVID-2019

Roman Woelfel et al.

NATURE (2020)

添加到收藏夹

Article Infectious Diseases

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)

Florian Kurth et al.

INFECTION (2020)

添加到收藏夹

Article Immunology

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

Daniela Weiskopf et al.

SCIENCE IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Julian Braun et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

Nina Le Bert et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

Lihong Liu et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Jose Mateus et al.

SCIENCE (2020)

添加到收藏夹

Article Immunology

Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein

Andrew P. Ferretti et al.

IMMUNITY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Ellen Shrock et al.

SCIENCE (2020)

添加到收藏夹

Review Multidisciplinary Sciences

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Angkana T. Huang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Microbiology

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee et al.

NATURE MICROBIOLOGY (2020)

添加到收藏夹

Article Immunology

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

Petra Bacher et al.

IMMUNITY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Kevin W. Ng et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Epitope similarity cannot explain the pre-formed T cell immunity towards structural SARS-CoV-2 proteins

Ulrik Stervbo et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Immunology

Cross-reactive memory T cells and herd immunity to SARS-CoV-2

Marc Lipsitch et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients

Nisreen M. A. Okba et al.

EMERGING INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Computer Science, Interdisciplinary Applications

The REDCap consortium: Building an international community of software platform partners

Paul A. Harris et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The SARS-CoV Fusion Peptide Forms an Extended Bipartite Fusion Platform that Perturbs Membrane Order in a Calcium-Dependent Manner

Alex L. Lai et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

添加到收藏夹

Review Immunology

Human memory T cells: generation, compartmentalization and homeostasis

Donna L. Farber et al.

NATURE REVIEWS IMMUNOLOGY (2014)

添加到收藏夹

Review Immunology

Origin and function of circulating plasmablasts during acute viral infections

Katja Fink

FRONTIERS IN IMMUNOLOGY (2012)

添加到收藏夹

Article Immunology

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center

Tanja A. Schwickert et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

添加到收藏夹

Article Biochemical Research Methods

Peptide binding predictions for HLA DR, DP and DQ molecules

Peng Wang et al.

BMC BIOINFORMATICS (2010)

添加到收藏夹

Review Hematology

Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets

Siegfried Kohler et al.

BLOOD (2009)

添加到收藏夹

Article Hematology

Cytokine-induced human IFN-γ-secreting effector-memory Th cells in chronic autoimmune inflammation

Arne Sattler et al.

BLOOD (2009)

添加到收藏夹

Article Computer Science, Interdisciplinary Applications

Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support

Paul A. Harris et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2009)

添加到收藏夹

Article Immunology

Germinal center reutilization by newly activated B cells

Tanja A. Schwickert et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

添加到收藏夹

Article Biochemical Research Methods

A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach

Peng Wang et al.

PLOS COMPUTATIONAL BIOLOGY (2008)

添加到收藏夹

Article Immunology

Cell activation state-governed formation of germinal centers following viral infection

Katja Fink et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

On the dynamics of TCR:CD3 complex cell surface expression and downmodulation

HY Liu et al.

IMMUNITY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.