4.8 Editorial Material

MICROBIOLOGY Giving antibiotics an assist

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Summary: The emergence of resistance to clinical antibiotics has prompted the development of a new antimicrobial strategy targeting the bacterial hydrogen sulfide (H2S) defense system. Inhibitors of the bacterial cystathionine g-lyase (CSE) have been found to enhance the effectiveness of bactericidal antibiotics against major human pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. These inhibitors also disrupt bacterial tolerance, reduce biofilm formation, and decrease the number of persister bacteria surviving antibiotic treatment.

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