☆ 4.8 Editorial Material

Host genetics influence the gut microbiome

SCIENCE (2021)

Large-scale association analyses identify host factors influencing human gut microbiome composition

Alexander Kurilshikov et al.

Summary: The study revealed significant effects of host genetic variation on microbial composition, with the lactase (LCT) gene locus showing an age-dependent association with Bifidobacterium abundance. Other associations, while suggestive, were enriched for taxa with high heritability and for genes expressed in the intestine and brain.

NATURE GENETICS (2021)

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Article Multidisciplinary Sciences

Gut microbiome heritability is nearly universal but environmentally contingent

Laura Grieneisen et al.

Summary: Analysis of 16,234 gut microbiome profiles from 585 wild baboons collected over 14 years revealed that host genetic effects on the gut microbiome are nearly universal. The study found that 97% of microbiome phenotypes were significantly heritable, with heritability being greater in the dry season, with low diet diversity, and in older hosts. These findings suggest the potential for selection on microbiome characteristics as a host phenotype.

SCIENCE (2021)

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Article Zoology