4.8 Editorial Material

Bispecific antibodies

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Article Oncology

A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies

Iris de Weerdt et al.

Summary: Novel T cell-based therapies show promise for treating B-cell malignancies, but issues of low efficacy and high toxicity have hindered progress. Targeting tumors with V gamma 9V delta 2 T cells using a bispecific antibody offers a new approach with high efficacy and limited toxicity potential.

CANCER IMMUNOLOGY RESEARCH (2021)

Article Cell Biology

Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy

Janelle C. Waite et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Review Cell Biology

Ab locks for improving the selectivity and safety of antibody drugs

Wen-Wei Lin et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

Article Medicine, Research & Experimental

Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody

Karin Staflin et al.

JCI INSIGHT (2020)

Article Medicine, Research & Experimental

Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies

Nathan D. Trinklein et al.

Review Biotechnology & Applied Microbiology

Bispecific antibodies: a mechanistic review of the pipeline

Aran F. Labrijn et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Multidisciplinary Sciences

On-target restoration of a split T cell-engaging antibody for precision immunotherapy

Agnes Banaszek et al.

NATURE COMMUNICATIONS (2019)

Review Medicine, Research & Experimental

The making of bispecific antibodies

Ulrich Brinkmann et al.

Article Biochemistry & Molecular Biology

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa et al.

NATURE MEDICINE (2012)